SYN-COLL is a patented tripeptide that mimics the body's natural thrombospondin-1 collagen synthesis activation signal. When thrombospondin-1 binds to its receptor on fibroblasts, it triggers collagen production. SYN-COLL mimics this binding, activating the same collagen synthesis pathway without a biological precursor molecule. A manufacturer study found SYN-COLL reduced the appearance of fine lines significantly within 28 days of twice-daily application. It is distinct from Syn-Ake (which targets muscle contraction), SYN-COLL directly stimulates fibroblast collagen production rather than addressing neuromuscular activity.

Soluble Collagen in serum form is collagen that has been hydrolysed into small enough fragments to remain suspended in a serum formula. In this form it acts as a powerful moisture-retaining conditioning agent, forming a breathable film on the skin surface that reduces water evaporation and provides immediate plumping effects. While debate continues about whether topical collagen fragments can penetrate deeply enough to stimulate dermal collagen production, soluble collagen's surface conditioning and moisture-retention effects are well-established and contribute meaningfully to the immediately visible skin plumpness that makes fine lines less noticeable.

Plankton extract is a marine-derived ingredient gaining attention in advanced skincare formulation. Certain plankton species produce compounds including UV-protective mycosporines and antioxidants adapted to extreme UV and environmental exposure in ocean surface environments. In skincare applications, plankton extracts have been studied for their effects on cellular energy production (similar to CoQ10 analogues), antioxidant protection, and skin regeneration signalling. South Beach Skin Lab's inclusion of Plankton Extract represents the more innovative and differentiated aspect of the formula, complementing the established peptide and collagen ingredients with a marine regenerative compound.

Sodium Hyaluronate is the salt form of Hyaluronic Acid with good skin penetration for deep hydration. Ascorbyl Glucoside is a stable Vitamin C ester that converts to active ascorbic acid in the skin, providing collagen synthesis cofactor activity and melanin inhibition for brightening. Together these two ingredients complete the formula's hydration and antioxidant coverage, supporting the surface and collagen effects of the Soluble Collagen and SYN-COLL respectively.